Numbness in the extremities and in the body are among the most common words a neurologist will hear in their office. The causes may vary, from the most innocent, such as purely psychological reasons without having an organic background, to more complex ones requiring special examinations and very careful investigation. Indicatively, the most common causes are the carpal tunnel syndrome, vitamin deficiency, neck or low back herniated discs, peripheral nerve damage, inflammatory and demyelinating disease of the central nervous system, metabolic causes such as diabetes mellitus, thyroid dysfunction, etc. For all of the above reasons, a detailed medical history and a complete neurological examination is required.